![]() How Do Pain Relievers Work? Johns Hopkins Medicine.Combined analgesics in (headache) pain therapy: shotgun approach or precise multi-target therapeutics?.Caffeine in the management of patients with headache. In the case of Excedrin pain relief products, caffeine boosts the pain-relieving effects of aspirin and acetaminophen making these medicines up to 40 more.Referenced text is highlighted in source PDF. If you have liver or kidney disease, talk to your doctor before taking acetaminophen.Įxcedrin has been a leader in headache relief for more than 50 years, and the range of Excedrin products contains something for every kind of headache, including tension headaches, nighttime headaches and migraines.ĭiscover the full Excedrin product range here, or, if you need more help finding the right product for you, try our interactive product selector. Do not take more than recommended dose, as this may be harmful, including serious harm to your liver. ![]() Acetaminophen is contained in many medicines to treat pain, fever, symptoms of cold and flu, and sleep medicines. Pain: Oral: Acetaminophen 1 g/caffeine 130 mg every 6 hours as needed (maximum: acetaminophen 3 g/caffeine 390 mg per 24 hours) Dosing: Geriatric. Excedrin is a combination of these ingredients: two pain relievers, plus an amplifier to enhance the analgesic effect.Īcetaminophen, also known as paracetamol, should not be taken with other medicines that also contain acetaminophen. Īcetaminophen, aspirin and caffeine, when taken as directed, provide clinically proven headache relief. This means less acetaminophen and aspirin is needed to relieve your migraine pain when combined with caffeine. Finally, caffeine has been shown to increase the potency of aspirin and acetaminophen by up to 40 percent. At 3 and 4 hours, the acetaminophen/aspirin combination as well as the aspirin/caffeine combination were significantly superior to acetaminophen alone. This allows you to tolerate more pain, therefore providing pain relief. However, it is believed to elevate the pain threshold. The way in which acetaminophen works is still not well understood. Aspirin helps to block the production of pain signaling chemicals called prostaglandins. Although caffeine may be most commonly used for its effect on alertness, it does have other effects on the body. Aspirin is a non-steroidal anti-inflammatory drug or NSAID. Its role as a stimulant is why you feel alert and a boost of energy when you consume caffeine. Įxcedrin’s specialized formula contains two pain relievers (acetaminophen and aspirin) plus an amplifier (caffeine) that work together to target head pain. Evidence suggests that the use of combination analgesics such as Excedrin offer advantages in the treatment of headaches by targeting pain in more than one way.
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